Reaction: 2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP
- in pathway: Fatty acyl-CoA biosynthesis
Estradiol 17-beta-dehydrogenase 8 (HSD17B8) (Ohno et al. 2008) forms a heterotetramer with carbonyl reductase family member 4 (CBR4) (Chen et al. 2009, Zhang et al. 2005). The heterotetramer has NADPH-dependent 3-ketoacyl-acyl carrier protein reductase activity which is suggested to play a role in biosynthesis of fatty acids in mitochondria (Venkatesan et al. 2014).
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
3HA-ACP [mitochondrial matrix]
3OA-ACP [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-8862152
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Reaction input - small molecules:
3-oxoacyl-[acyl-carrier-protein]
hydron
NADPH
Reaction output - small molecules:
NADP(+)
(3R)-3-hydroxyacyl-[acyl-carrier-protein]
Reactome.org link: R-HSA-8862152