Reaction: USP48 cleaves polyubiquitin
- in pathway: Ub-specific processing proteases
USP48 (confusingly referred to as USP31 in some literature) is a deubiquitinating enzyme that cleaves preferentially lysine-63-linked polyubiquitin chains. USP48 can also cleave lysine-48-linked polyubiquitin chains albeit to a lesser extent. USP48 can interact with TRAF2, and overexpression of USP48 inhibits NF-?B activation suggesting that it may remove ubiquitin from TRAF2, TRAF6 or another essential intermediate that lies downstream of TRAFs.
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-8862184
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-8862184