Reaction: Influx of extracellular calcium
- in pathway: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Beta amyloid increases influx of extracellular calcium (Ca2+) through the plasma membrane, thus increasing the cytosolic Ca2+ concentration. The mechanism has not been completely elucidated (Lee et al. 2000, Abramov et al. 2004).
Reaction - small molecule participants:
Ca2+ [cytosol]
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-8863009
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
calcium(2+)
Reactome.org link: R-HSA-8863009