Reaction: p25-bound CDK5 phosphorylates CDC25C
- in pathway: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
CDK5 activated by binding to p25 phosphorylates CDC25C protein tyrosine phosphatase at serine and threonine residues T48, T67, S122, T130, S168, and S214. CDK5-mediated phosphorylation of CDC25C interferes with 14-3-3-epsilon (YWHAE) mediated retention of CDC25C in the cytosol. Once activated by CDK5, CDC25C promotes activation of CDK1 (Chang et al. 2012).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8863011
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8863011