Reaction: p25-bound CDK5 phosphorylates CDC25A
- in pathway: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
CDK5, activated by binding to p25, phosphorylates CDC25A protein tyrosine phosphatase at serine residues S40, S116 and S261. CDC25A mainly localizes to the nucleus in neurons and CDK5-mediated phosphorylation does not change its localization. Once activated by CDK5, CDC25A promotes activation of CDK1, CDK2 and CDK4 (Chang et al. 2012).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-8863014
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8863014