Reaction: PTPN12 dephosphorylates PDGFRB at Y1021
- in pathway: Signaling by PDGF
Protein tyrosine phosphatase PTNP12 dephosphorylates activated PDFRB (PDGF receptor beta) at tyrosine residue Y1021, which contributes to the tumor suppressor role of PTPN12 in triple negative breast cancer in addition to PTPN12-mediated dephosphorylation of ERBB2 (HER2) at Y1248 (Sun et al. 2011).
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-8864036
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-8864036