Reaction: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
- in pathway: ABC-family proteins mediated transport
Retrotranslocation of the misfolded CFTR likely depends on the ERAD ATPase VCP (reviewed in Vembar and Brodsky, 2008; Pranke and Sermet-Gaudelus, 2014).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8866542
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-8866542