Reaction: OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane
- in pathway: Acyl chain remodelling of PS
Phosphatidylserine (PS) is a lipid component of cellular membranes. It is synthesised in the endoplasmic reticulum and then preferentially associates with the inner leaflet of the plasma membrane by as-yet unknown mechanisms. Intracellular lipids can travel through aqueous phases via transport vesicles or lipid-transfer proteins (LTPs). Oxysterol-binding protein-related proteins 5, 8 and 10 (OSBPL5, OSBPL8 and OSBPL10) bind and transport PS from ER compartments to the plasma membrane. They tether the ER to the plasma membrane via interaction of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (PI4P) and mediate PI4P/PS countertransport between the ER and the plasma membrane (Du et al. 2011, Chung et al. 2015, Perttila et al. 2009, Maeda et al. 2013). OSBPL10 is also implicated in apolipoprotein B100 secretion (Nissila et al. 2012).
Reaction - small molecule participants:
PS [plasma membrane]
PI4P [endoplasmic reticulum membrane]
PI4P [plasma membrane]
PS [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-8867876
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4-phosphate
3-sn-phosphatidyl-L-serine
Reaction output - small molecules:
3-sn-phosphatidyl-L-serine
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reactome.org link: R-HSA-8867876