Reaction: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
- in pathway: Clathrin-mediated endocytosis
Clathrin-associated PIK3C2A catalyzes the conversion of PI(4)P to PI(3,4)P2, which contributes to the recruitment of BAR domain proteins such as SNX9 to the clathrin-coated pit (Domin et al, 2000; Gaidarov et al, 2001; Gaidarov et al, 2005; Posor et al, 2013; reviewed in Daumke et al, 2014).
Reaction - small molecule participants:
ADP [cytosol]
PI(3,4)P2 [plasma membrane]
ATP [cytosol]
PI4P [plasma membrane]
Reactome.org reaction link: R-HSA-8868072
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reactome.org link: R-HSA-8868072