Reaction: NMRK2 phosphorylates NAR to yield NAMN
- in pathway: Nicotinate metabolism
NMRK2 (nicotinamide riboside kinase 2) catalyzes the reaction of NAR (N-ribosylnicotinate) and ATP to yield NAMN (beta-nicotinate D-ribonucleotide), ADP, and H+ (Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK2 is a cytosolic enzyme (Nikiforov et al. 2011), localized predominantly in myocytes (Li et al. 1999).
Reaction - small molecule participants:
H+ [cytosol]
ADP [cytosol]
NAMN [cytosol]
ATP [cytosol]
NAR [cytosol]
Reactome.org reaction link: R-HSA-8869607
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Reaction input - small molecules:
ATP(4-)
D-ribosylnicotinate
Reaction output - small molecules:
hydron
ADP(3-)
nicotinic acid D-ribonucleotide
Reactome.org link: R-HSA-8869607