Reaction: NMRK2 phosphorylates NR to yield NMN
- in pathway: Nicotinate metabolism
NMRK2 (nicotinamide riboside kinase 2) catalyzes the reaction of NR (N-ribosylnicotinamide) and ATP to yield NMN (beta-nicotinamide D-ribonucleotide), ADP, and H+ (Bieganowsky & Brenner 2004; Tempel et al. 2007). The reaction is annotated with ATP(4-), the major ionized form of ATP at pH 7.2 (Stockbridge & Wolfenden 2009), as the phosphate donor. NMRK2 is a cytosolic enzyme (Nikiforov et al. 2011), localized predominantly in myocytes (Li et al. 1999).
Reaction - small molecule participants:
NMN [cytosol]
H+ [cytosol]
ADP [cytosol]
ATP [cytosol]
NR [cytosol]
Reactome.org reaction link: R-HSA-8869627
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Reaction input - small molecules:
ATP(4-)
N-ribosylnicotinamide
Reaction output - small molecules:
NMN(-)
hydron
ADP(3-)
Reactome.org link: R-HSA-8869627