Reaction: PLEKHA3,8 bind PI4P, ARF1
- in pathway: Synthesis of PIPs at the plasma membrane
Proteins with the plekstrin homology (PH) domain are able to bind specific phosphoinositides. Pleckstrin homology domain-containing family A members 3 and 8 (PLEKHA3 and PLEKHA8 aka FAPP1 and FAPP2) specifically bind phosphoinositide 4-phosphate (PI4P, PtdIns(4)P), a key intermediate in the synthesis of phosphoinositide 4,5-diphosphate (PIP2). PLEKHA3 and 8 are localised to the trans-Golgi network (TGN) where they interact with PI4P and the small GTPase ADP-ribosylation factor (ARF1) through their PH domains and mediate the transport of lipid cargo from the Golgi to the plasma membrane (Godi et al. 1999, Godi et al. 2004).
Reaction - small molecule participants:
PI4P [Golgi membrane]
Reactome.org reaction link: R-HSA-8870499
======
Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reaction output - small molecules:
Reactome.org link: R-HSA-8870499