Reaction: CDK5:p25 phosphorylates FOXO3
- in pathway: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
CDK5, aberrantly activated by binding to p25, phosphorylates transcription factor FOXO3 on serine residues S43, S173, S294 and S325 (Shi et al. 2016).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8870558
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8870558