Reaction: ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH
- in pathway: Mitochondrial Fatty Acid Beta-Oxidation
Mitochondrial 3-ketoacyl-CoA thiolase (ACAA2) is a mitochondrial matrix enzyme involved in fatty acid beta-oxidation, transferring the acyl group from acyl-CoA (acyl-CoA) to acetyl-CoA (Ac-CoA) to form 3-oxyoacyl-CoA (3OA-CoA) and CoA-SH (Abe et al. 1993, Middleton 1973).
Reaction - small molecule participants:
CoA-SH [mitochondrial matrix]
3OA-CoA [mitochondrial matrix]
Ac-CoA [mitochondrial matrix]
acyl-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-8874745
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Reaction input - small molecules:
acetyl-CoA(4-)
acyl-CoA
Reaction output - small molecules:
coenzyme A(4-)
3-oxo-fatty acyl-CoA
Reactome.org link: R-HSA-8874745