Reaction: SLC26A11 transports SO4(2-) from extracellular region to cytosol
- in pathway: Multifunctional anion exchangers
Lymphocytes migrate from the blood into most secondary lymphoid organs and chronically inflamed tissues through high endothelial venules (HEV). HEV endothelial cells (HEVECs) incorporate large amounts of sulfate into sialomucin-type counter-receptors for the lymphocyte-homing receptor L-selectin. Sulfate uptake into HEVECs is mediated by two functionally-distinct classes of sulfate transporters: Na+-coupled transporters and sulfate/anion exchangers. Sodium-independent sulfate anion transporter SLC26A11 is targeted to the cell membrane and displays Na+-independent sulfate transport activity. SLC26A11 is expressed in kidney, brain and placenta and at lower levels in other tissues (Vincourt et al. 2003).
Reaction - small molecule participants:
SO4(2-) [cytosol]
SO4(2-) [extracellular region]
Reactome.org reaction link: R-HSA-8875871
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Reaction input - small molecules:
sulfate
Reaction output - small molecules:
sulfate
Reactome.org link: R-HSA-8875871