Reaction: CHOL translocates from lysosome membrane to ER membrane
- in pathway: LDL clearance
In macrophages, the hydrolysis of cholesteryl esters (CHESTs) is the rate-limiting step in the removal of free cholesterol (CHOL) from these cells. CHOL is transported via transport vesicles and can be used for cellular functions or removed from the cell by ABCA1 to create new HDL particles. Accumulation of CHESTs in macrophage foam cells is key to atherosclerotic plaque formation (Dubland & Francis 2015).
CHOL is positioned on the outer membrane of lysosomes and translocates to the ER membrane where it can be re-esterified for storage. The mechanism of translocation is currently unknown (Infante et al. 2008).
Reaction - small molecule participants:
CHOL [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-8876485
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Reaction input - small molecules:
Reaction output - small molecules:
cholesterol
Reactome.org link: R-HSA-8876485