Reaction: SRC phosphorylates InlA-bound CDH1 and CTNNB1
SRC-mediated phosphorylation of E-cadherin (CDH1) is needed for InlA-mediated entry of Listeria monocytogenes into host cells (Bonazzi et al. 2008). At cell adhesion sites, SRC is known to phosphorylate CDH1 at tyrosine residues Y753 and Y754 and CDH1-bound beta-catenin (CTNNB1) at an unknown tyrosine residue. SRC-phosphorylated tyrosines of CDH1 and CTNNB1 serve as docking sites for the E3 ubiquitin ligase Hakai (CBLL1) (Fujita et al. 2002, Mukherjee et al. 2012).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8876948
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8876948