Reaction: PXLP-K405-GAD1 decarboxylates L-Glu to form GABA
- in pathway: GABA synthesis
GAD1 (GAD67) is evenly spread throughout the neuronal cytoplasm and is invoved in GABA synthesis that is used for synaptogenesis, protection against neural injury and as an energy source through the GABA shunt.
Reaction - small molecule participants:
GABA [cytosol]
CO2 [cytosol]
L-Glu [cytosol]
H+ [cytosol]
Reactome.org reaction link: R-HSA-888572
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Reaction input - small molecules:
L-glutamate(1-)
hydron
Reaction output - small molecules:
gamma-aminobutyric acid zwitterion
carbon dioxide
Reactome.org link: R-HSA-888572