Reaction: Release of GABA at the synapse
- in pathway: GABA synthesis, release, reuptake and degradation
GABA synaptic vesicles are fused to the presynaptic terminal membrane with the help of SNARE complex proteins, synaptobrevin located in the synaptic vesicle, SNAP 25 and syntaxin located in the plasma membrane. Complexin optimizes partially assembled SNARES for Ca2+ dependent exocytosis. Fusion of the synaptic vesicle is triggered by the influx of Ca2+ through N, P/Q Ca2+ channels, which binds to synaptobrevin on the synaptic vesicles triggering a series of steps leading to fusion of the synaptic vesicle to the presynatic terminal membrane and release of GABA.
Reaction - small molecule participants:
GABA [extracellular region]
Ca2+ [cytosol]
Reactome.org reaction link: R-HSA-888589
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
gamma-aminobutyric acid zwitterion
Reactome.org link: R-HSA-888589