Reaction: PKC phosphorylates NFE2L2
- in pathway: KEAP1-NFE2L2 pathway
In response to oxidative stress, protein kinase C (PKC) phosphorylates NFE2L2 (NRF2) at residue serine 40 (Ser-40). It has been demonstrated that NRF2 phosphorylation at Ser-40 facilitates its nuclear translocation (Huang et al. 2002).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8932284
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8932284