Reaction: CK2 phosphorylates NFE2L2
- in pathway: KEAP1-NFE2L2 pathway
Upon stimulation by oxidative/electrophilic stress, Nuclear factor erythroid 2-related NFE2L2 (NRF2) is phosphorylated at the transcription activation domain (TA) by Casein kinase 2 (CK2). Deletional analysis revealed the transcription activation domains Neh4 (Nrf2-ECH homology 4) and Neh5 (Nrf2-ECH homology 5) as major regions necessary for the phosphorylation. The phosphorylation of these sites correlates with NFE2L2 translocation into the nucleus and this translocation is reduced in the presence of a CK2 inhibitor (Apopa et al. 2008, Pi et al. 2007).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8932322
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8932322