Reaction: PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE
- in pathway: Synthesis of 5-eicosatetraenoic acids
Serum paraoxonase/arylesterases 1, 2 and 3 (PON1,2 and 3) are extracellular lactonases/lactonysing enzymes with overlapping, but also distinct substrate specificity. PONs are homodimeric proteins which bind 2 Ca2+ ions per subunit, necessary for enzyme stability and enzymatic activity. All three PONs can efficiently metabolise 5-hydroxy-eicosatetraenoic acid 1,5-lactone (5-HETEL), a product of both enzymatic and nonenzymatic oxidation of arachidonic acid and may represent one of the PONs' endogenous substrates (Draganov et al. 2005).
Reaction - small molecule participants:
5-HETE [extracellular region]
H2O [extracellular region]
5-HETEL [extracellular region]
Reactome.org reaction link: R-HSA-8932633
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Reaction input - small molecules:
water
meadowlactone
Reaction output - small molecules:
5-HETE
Reactome.org link: R-HSA-8932633