Reaction: SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane
- in pathway: Serine biosynthesis
Serine incorporators 1-5 (SERINC1-5) are membrane-associated proteins that incorporate the polar amino acid serine (L-Ser) into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipids. SERINC3 and 5 have recently been identified to be restrictors to HIV replication in human cells (Fackler 2015, Usami et al. 2015).
Reaction - small molecule participants:
L-Ser [plasma membrane]
L-Ser [cytosol]
Reactome.org reaction link: R-HSA-8932980
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Reaction input - small molecules:
L-serine zwitterion
Reaction output - small molecules:
L-serine zwitterion
Reactome.org link: R-HSA-8932980