Reaction: Activated PKC phosphorylates SHC1
- in pathway: SHC1 events in ERBB2 signaling
Activated protein kinase C alpha (PRKCA), as well as delta (PRKCD) and epsilon (PRKCE), can phosphorylate SHC1 splicing isoforms SHC1-1 (p66Shc) and SHC1-2 (p52Shc) on serine residues S139 and S29, respectively (Habib et al. 1994, Faisal et al. 2002).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8934446
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8934446