Reaction: phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine
- in pathway: Phenylalanine metabolism
CCBL1 (KAT 1) catalyzes the reaction of phenylalanine and pyruvate to form 3-(indol-3-yl)pyruvate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).
Reaction - small molecule participants:
L-Ala [cytosol]
3IN-PYRA [cytosol]
L-Phe [cytosol]
PYR [cytosol]
Reactome.org reaction link: R-HSA-893593
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Reaction input - small molecules:
L-phenylalanine zwitterion
pyruvate
Reaction output - small molecules:
L-alanine zwitterion
3-(indol-3-yl)pyruvic acid
Reactome.org link: R-HSA-893593