Reaction: glutamine + pyruvate => 2-oxoglutaramate + alanine
- in pathway: Glutamate and glutamine metabolism
CCBL1 (KAT 1) catalyzes the reaction of glutamine and pyruvate to form 2-oxoglutaramate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).
Reaction - small molecule participants:
L-Ala [cytosol]
2OGA [cytosol]
PYR [cytosol]
L-Gln [cytosol]
Reactome.org reaction link: R-HSA-893616
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Reaction input - small molecules:
pyruvate
L-glutamine zwitterion
Reaction output - small molecules:
L-alanine zwitterion
2-oxoglutaramic acid
Reactome.org link: R-HSA-893616