Reaction: MARC1,MARC2 reduce N-hydroxylated compounds
- in pathway: Phase I - Functionalization of compounds
Mitochondrial amidoxime-reducing components 1 and 2 (MARC1 and 2) are Mo-molybdopterin (Mo-MPT) cofactor-dependent, outer mitochondrial membrane-associated enzymes capable of reducing N-hydroxylated prodrugs and N-hydroxy-L-arginine (NOHA) and N-hydroxy-N-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. They are components of an N-hydroxylated prodrug-converting complex, also containing cytochrome b5 (CYB5B) and NADH cytochrome b5 reductase 3 (CYB5R3) (Jakobs et al. 2014, Gruenewald et al. 2008, Ott et al. 2014, 2015). The reduction of NOHA is described in this reaction.
Reaction - small molecule participants:
H2O [cytosol]
L-Arg [cytosol]
NAD+ [cytosol]
H+ [cytosol]
NOHA [cytosol]
NADH [cytosol]
Reactome.org reaction link: R-HSA-8936442
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Reaction input - small molecules:
hydron
N(omega)-hydroxyarginine
NADH(2-)
Reaction output - small molecules:
water
L-argininium(1+)
NAD(1-)
Reactome.org link: R-HSA-8936442