Reaction: ENPPs hydrolyse CoA-SH to PPANT, PAP
- in pathway: Vitamin B5 (pantothenate) metabolism
Coenzyme A (CoA-SH) in serum can be hydrolysed by ectonucleotide pyrophosphatases (ENPPs) (Goding et al. 2003), which have pantothenate kinase activity. The products of this are adenosine 3',5'-bismonophosphate (PAP) and 4′-phosphopantetheine (PPANT), which is able to translocate into cells providing an alternative source for intracellular coenzyme A biosynthesis (Srinivasan et al. 2015).
Reaction - small molecule participants:
PPANT [extracellular region]
PAP [extracellular region]
H2O [extracellular region]
CoA-SH [extracellular region]
Reactome.org reaction link: R-HSA-8938314
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Reaction input - small molecules:
water
coenzyme A(4-)
Reaction output - small molecules:
D-pantetheine 4'-phosphate(2-)
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-8938314