Reaction: FOLR2 binds FOLA
- in pathway: Metabolism of folate and pterines
The folate receptor beta (FOLR2, FBP) (Ratnam et al. 1989) binds folate (FOLA) and reduced folic acid derivatives and mediates their delivery into cells (Antony et al. 1985). Antifolates are folate analogues that inhibit vitamin B9 (folic acid)-using cellular enzymes are used in the treatment of cancer and inflammatory diseases. Targeting FOLR2 may be a way to investigate novel folate-based drugs in the treatment of these diseases (Wibowo et al. 2013).
Reaction - small molecule participants:
FOLA [extracellular region]
Reactome.org reaction link: R-HSA-8940134
======
Reaction input - small molecules:
folic acid
Reaction output - small molecules:
Reactome.org link: R-HSA-8940134