Reaction: FUNDC1 is phosphorylated by ULK1 at Ser17
- in pathway: Receptor Mediated Mitophagy
At mitochondria, ULK1 interacts with FUNDC1, phosphorylating it at serine 17, which enhances FUNDC1 binding to LC3. FUNDC1 regulates ULK1 recruitment to damaged mitochondria; FUNDC1 phosphorylation by ULK1 is crucial for mitophagy.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8948146
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8948146