Reaction: TNKS and TNKS2 PARylate PTEN
- in pathway: Regulation of PTEN stability and activity
PTEN can bind tankyrases TNKS (TNKS1) and TNKS2. The interaction involves the tankyrase binding motif at the N-terminus of PTEN (RYQEDG). TNKS and TNKS2 poly-ADP-ribosylate (PARylate) PTEN on glutamic acid residues E40 and E150 and on aspartic acid residue D326. PTEN PARylation is a pre-requisite for RNF146-mediated ubiquitination of PTEN (Li et al. 2015).
Reaction - small molecule participants:
NAM [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-8948800
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
Reactome.org link: R-HSA-8948800