Reaction: VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space
- in pathway: Mitochondrial calcium ion transport
VDAC1, VDAC2, and VDAC3 are voltage dependent anion channels that also preferentially transport divalent calcium ions (Ca2+) in their closed state (Rapizzi et al. 2002, De Stefani et al. 2012, Checchetto et al. 2014, and inferred from rat VDAC1). VDAC1, VDAC2, and VDAC3, located in the mitochondrial outer membrane, transport Ca2+ from the cytosol to the mitochondrial intermembrane space. Transfer of cytosolic calcium to the intermembrane space appears to occur preferentially at sites where the endoplasmic reticulum is in close proximity to the mitochondrial outer membrane. This apposition is due to the physical interaction of VDAC channels on the mitochondrial outer membrane with the ITPR1 (IP3R) channel on the endoplasmic reticulum via the chaperone HSPA9 (GRP75) (Szabadkai et al. 2006).
Reaction - small molecule participants:
Ca2+ [mitochondrial intermembrane space]
Ca2+ [cytosol]
Reactome.org reaction link: R-HSA-8949145
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
calcium(2+)
Reactome.org link: R-HSA-8949145