Reaction: SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)
- in pathway: Mitochondrial calcium ion transport
NCLX catalyzes the exchange of 3-4 sodium ions from the intermembrane space for 1 calcium ion from the mitochondrial matrix (Palty et al. 2010, De Marchi et al. 2014). As a result, NCLX causes an efflux of calcium from the mitochondrial matrix and thereby attenuates calcium regulation of enzymatic activity within the mitochondrial matrix.
Reaction - small molecule participants:
Ca2+ [mitochondrial intermembrane space]
Na+ [mitochondrial matrix]
Na+ [mitochondrial intermembrane space]
Ca2+ [mitochondrial matrix]
Reactome.org reaction link: R-HSA-8949688
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Reaction input - small molecules:
sodium(1+)
calcium(2+)
Reaction output - small molecules:
calcium(2+)
sodium(1+)
Reactome.org link: R-HSA-8949688