Reaction: SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)
- in pathway: Mitochondrial calcium ion transport
As inferred from rat Slc8a3 and mouse Akap1 (Akap121), SLC8A3 in a complex with AKAP1 exchanges cytosolic sodium ions for divalent calcium from the mitochondrial intermembrane space resulting in an efflux of calcium from the mitochondrion. The mitochondrial localization of SLC8A3 is controversial, however, and SLC8A3 has a limited tissue distribution.
Reaction - small molecule participants:
Na+ [mitochondrial intermembrane space]
Ca2+ [cytosol]
Ca2+ [mitochondrial intermembrane space]
Na+ [cytosol]
Reactome.org reaction link: R-HSA-8949703
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Reaction input - small molecules:
calcium(2+)
sodium(1+)
Reaction output - small molecules:
sodium(1+)
calcium(2+)
Reactome.org link: R-HSA-8949703