Reaction: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
- in pathway: Interleukin-23 signaling
Interleukin-23 (IL23) induces Signal transducer and activator of transcription 3 (STAT3) and STAT4 phosphorylation. Non-receptor tyrosine-protein kinase TYK2 (TYK2) and Tyrosine-protein kinase JAK2 (JAK2) are believed to phosphorylate STAT3 and STAT4 (Parham et al. 2002). STAT3 is the most prominent STAT activated by IL23, contrasting with Interleukin-12 (IL12) which predominantly induces STAT4 activation (Parham et al. 2002). IL23 induces phosphorylation of STAT3 and STAT4 in NK-like T cells but neither in NK cells (van de Wetering et al. 2009). Phosphorylation results in STAT3:STAT4 heterodimer formation (Parham et al. 2002).
This is a black box event because the exact mechanism and order of STAT3/STAT4 binding is unknown.
This is a black box event because the exact mechanism and order of STAT3/STAT4 binding is unknown.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8950269
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8950269