Meta-Biol

• Pathways

Interleukin-27 receptor is formed by Interleukin-27 receptor subunit alpha (IL27RA, WSX-1) and Interleukin-27 receptor subunit beta (IL6ST, gp130). Both subunits can be tyrosine phosphorylated after ligand-receptor interaction (Pflanz et al. 2004, Takeda et al. 2003). There is general agreement that ligand binding to cytokine receptors results in the activation of prebound Jak kinases, which auto- and transphosphorylate then phosphorylate key tyrosine residues on the receptor (O'Shea et al 2002), but for the interleukin-27 receptor the pattern of phosphorylations is not clear, hence this is represented as a black box event.