Reaction: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
- in pathway: Interleukin-12 signaling
Inferred from mouse:
Signal transducer and activator of transcription 4 (STAT4) is activated via interaction with tyrosine-800 of Interleukin-12 receptor beta 2 subunit (IL12RB2). Based on experiments with murine-specific peptides, STAT4 activation depends on interaction with the peptide sequence pYLPSNID, where pY represents phosphotyrosine. STAT1 and STAT3 are not activated directly through the Interleukin-12 heterodimeric receptor (Naeger et al. 1999).
As the pattern of phosphorylations required for this event is unclear, it is represented here as a black box event.
Signal transducer and activator of transcription 4 (STAT4) is activated via interaction with tyrosine-800 of Interleukin-12 receptor beta 2 subunit (IL12RB2). Based on experiments with murine-specific peptides, STAT4 activation depends on interaction with the peptide sequence pYLPSNID, where pY represents phosphotyrosine. STAT1 and STAT3 are not activated directly through the Interleukin-12 heterodimeric receptor (Naeger et al. 1999).
As the pattern of phosphorylations required for this event is unclear, it is represented here as a black box event.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8950354
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8950354