Reaction: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
- in pathway: Interleukin-12 signaling
Interleukin-12 phosphorylates and thereby activates Tyrosine-protein kinase JAK2 (JAK2) and non-receptor tyrosine-protein kinase TYK2 (TYK2) (Bacon et al.1995, Kanda & Watanabe 2008).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8950423
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8950423