Reaction: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
- in pathway: Interleukin-27 signaling
Interleukin 27 phosphorylates/activates Tyrosine protein kinase JAK2 (JAK2) , non receptor tyrosine protein kinase TYK2 (TYK2) and Tyrosine protein kinase JAK1 (JAK1) (Kanda & Watanabe 2008). JAK1 interacts with IL27RA (Takeda et al 2003 )
As the phosphorylation required for Interleukin 27 induced activation are not clear, this is represented here as a black box event.
As the phosphorylation required for Interleukin 27 induced activation are not clear, this is represented here as a black box event.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8950537
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8950537