Reaction: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
- in pathway: Interleukin-23 signaling
In human cells IL-23 binding leads to phosphorylation and activation of TYK2 and JAK2 (Parham et al 2002).
Inferred from mouse:
The intracellular domain of Interleukin 12 receptor beta 1 subunit (Il12rb1), spanning amino acid residues 592–656, is crucial for Interleukin 23 complex–induced cellular proliferation and Signal transducer and activator of transcription 3 (Stat3) phosphorylation (Floss et al. 2016).
As it is not clear what induces JAK2 and TYK2 kinase phosphorylation this is represented here as a black box event.
The intracellular domain of Interleukin 12 receptor beta 1 subunit (Il12rb1), spanning amino acid residues 592–656, is crucial for Interleukin 23 complex–induced cellular proliferation and Signal transducer and activator of transcription 3 (Stat3) phosphorylation (Floss et al. 2016).
As it is not clear what induces JAK2 and TYK2 kinase phosphorylation this is represented here as a black box event.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8950591
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8950591