Reaction: EP300 acetylates RUNX3
- in pathway: RUNX3 regulates p14-ARF
EP300 (p300) histone acetyltransferase acetylates RUNX3 on lysine residues K94 and K171 (Lee et al. 2013), and probably other lysines (Jin et al. 2004). EP300-mediated acetylation of RUNX3 is positively regulated by TGF-beta treatment. Besides increasing the transcriptional activity of RUNX3, EP300-mediated acetylation also increases the half-life of RUNX3, as it interferes with SMURF-mediated ubiquitination and subsequent degradation of RUNX3 (Jin et al. 2004).
Reaction - small molecule participants:
CoA-SH [nucleoplasm]
Ac-CoA [nucleoplasm]
Reactome.org reaction link: R-HSA-8951966
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-8951966