Reaction: SLC38A9 transports L-Arg from lysosomal lumen to cytosol
- in pathway: MTOR signalling
The sodium-coupled neutral amino acid transporter 9 (SLC38A9 aka URLC11) is a lysosomal membrane protein mediating the transport of amino acids, especially L-arginine (Wang et al. 2015). It is proposed SLC38A9 acts as an amino acid sensor of the Ragulator and Rag GTPases complexes which are involved in the activation of mTORC1. The serine/threonine kinase mTORC1 regulates cellular homeostasis in response to many stimuli, such as nutrient status (for example via the transport of amino acids by SLC38A9) and energy level. SLC38A9 has been established to be an integral part of the Ragulator:Rag GTPase complex (Rebsamen et al. 2015, Wang et al. 2015, Jung et al. 2015).
Reaction - small molecule participants:
L-Arg [cytosol]
L-Arg [lysosomal lumen]
Reactome.org reaction link: R-HSA-8952726
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Reaction input - small molecules:
L-argininium(1+)
Reaction output - small molecules:
L-argininium(1+)
Reactome.org link: R-HSA-8952726