Reaction: MECR dimer reduces tdec2-CoA to DEC-CoA
- in pathway: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Mitochondrial trans-2-enoyl-CoA reductase (MECR aka NBRF1) is a dimeric oxidoreductase with a preference for short and medium chain trans fatty acyl-CoA substrates and may play a role in mitochondrial fatty acid synthesis (Chen et al. 2008). MECR is able to reduce trans acyl-CoA substrates of chain length C6 to C16 in an NADPH-dependent manner (Miinalainen et al. 2003). A representative reaction described here is the reduction of trans-dec-2-enoyl-CoA (tdec2-CoA) to decanoyl-CoA (DEC-CoA).
Reaction - small molecule participants:
DEC-CoA [mitochondrial matrix]
NADP+ [mitochondrial matrix]
tdec2-CoA [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-8952873
======
Reaction input - small molecules:
trans-dec-2-enoyl-CoA
hydron
NADPH
Reaction output - small molecules:
decanoyl-CoA
NADP(+)
Reactome.org link: R-HSA-8952873