Reaction: ADPRHL2 hydrolyses poly(ADP-ribose)
- in pathway: POLB-Dependent Long Patch Base Excision Repair
Important cellular processes such as DNA repair, cellular differentiation, and carcinogenesis are regulated by poly(ADP-ribosyl)ation. Previously, only the nuclear protein poly(ADP-ribose) glycohydrolase (PARG) has been identified to hydrolyse poly(ADP-ribose). Poly(ADP-ribose) glycohydrolase ARH3 (ADPRHL2) is a mitochondrial matrix protein (Niere et al. 2008) structurally unrelated to PARG but possessing PARG activity (Oka et al. 2006). ADPRHL2 is able to hydrolyse poly(ADP-ribose) in mitochondria (Niere et al. 2012).
Reaction - small molecule participants:
ADP-ribose [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-8952903
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Reaction input - small molecules:
water
Reaction output - small molecules:
ADP-D-ribose(2-)
Reactome.org link: R-HSA-8952903