Meta-Biol

• Pathways

Podocalyxin-like protein 2 (PODXL2 aka endoglycan) acts as a ligand for vascular selectins which mediate the rapid rolling of leukocytes over vascular surfaces. PODXL2 interacts with selectins through sulfation on two tyrosine residues (97 and 118) (Fieger et al. 2003, Kerr et al. 2008) and O-linked carbohydrate structures within its acidic amino-terminal region (latter not shown here). Protein-tyrosine sulfotransferases 1 and 2 (TPST1 and TPST2) are Golgi membrane-resident proteins which catalyse the transfer of sulfate from 3'-phospho-5'-adenylyl sulfate (PAPS) to tyrosine residues within acidic motifs of polypeptides such as PODXL2 (Ouyang et al. 1998, Danan et al. 2008, Teramoto et al. 2013).