Meta-Biol

• Pathways

Mitochondrial cardiolipin hydrolase (PLD6 aka MitoPLD) is located on the outer mitochondrial membrane and promotes trans-mitochondrial membrane adherence (mitochondrial fusion) in a Mfn-dependent manner by hydrolysing cardiolipin to generate the acidic fusogenic lipid phosphatidic acid (PA) and phosphatidylglycerol (PG) (Choi et al. 2006). Although cardiolipin is primarily an inner mitochondrial membrane-located protein, the outer mitochondrial membrane also contains around 10-20% cardiolipin and cardiolipin has been shown to translocate in a regulatable manner between the compartments (Liu et al. 2003). Mitoguardin 1 and 2 (MIGA1 and MIGA2) are regulators of mitochondrial membrane fusion. They form homo- or hetero-dimers at the mitochondrial outer membrane where they interact with PLD6 to stabilise it and/or facilitate PLD6 dimer formation (Zhang et al. 2016).