Reaction: NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA
- in pathway: Aspartate and asparagine metabolism
N-acetylaspartate (NAA) is a highly abundant brain metabolite which delivers the acetate moiety for synthesis of acetyl-CoA, further utilised for fatty acid generation. In the mitochondrial matrix of neuronal cells, N-acetylaspartate synthetase (NAT8L) catalyses the formation of NAA from acetyl-CoA (Ac-CoA) and L-aspartatic acid (L-Asp) (Wiame et al. 2009, Pessentheiner et al. 2013, Prokesch et al. 2016).
Reaction - small molecule participants:
CoA-SH [mitochondrial matrix]
NAA [mitochondrial matrix]
H+ [mitochondrial matrix]
Ac-CoA [mitochondrial matrix]
L-Asp [mitochondrial matrix]
Reactome.org reaction link: R-HSA-8954468
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Reaction input - small molecules:
acetyl-CoA(4-)
L-aspartate(1-)
Reaction output - small molecules:
coenzyme A(4-)
N-acetyl-L-aspartic acid
hydron
Reactome.org link: R-HSA-8954468