Reaction: PGP:Mg2+ dimer hydrolyses 3PG to glycerol
- in pathway: Glycolysis
Glycerol-3-phosphate (aka 3-phospho-D-glycerate, 3PG) is a metabolic intermediate of glucose, lipid and energy metabolism. Its cellular levels may be regulated by cytosolic glycerol-3-phosphate phosphatase (PGP aka G3PP), which hydrolyses 3PG to glycerol. PGP functions as a homodimer, binding one Mg2+ ion per subunit. The function of the human protein is inferred from rat Pgp characterisation and functional studies (Mugabo et al. 2016).
Reaction - small molecule participants:
Pi [cytosol]
Glycerol [cytosol]
H2O [cytosol]
3PG [cytosol]
Reactome.org reaction link: R-HSA-8955794
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Reaction input - small molecules:
water
3-phosphonato-D-glycerate(3-)
Reaction output - small molecules:
hydrogenphosphate
glycerol
Reactome.org link: R-HSA-8955794