Reaction: RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA
- in pathway: Fatty acyl-CoA biosynthesis
Polycistronic transcripts, where a single mRNA can encode several different polypeptide chains, are common in prokaryotes. In humans, only 3 bicistronic transcripts have been characterised to date. Human cDNAs encoding both RPP14 of the RNase P complex and mitochondrial 3-hydroxyacyl thioester dehydratase (HTD2) have been isolated. HTD2 functions in the mitochondrial fatty acid synthesis (FAS) pathway, dehydrating (3R)-hydroxyacyl-CoA (3HA-CoA) to trans-2-enoyl-CoA (t2E-CoA) (Autio et al. 2008).
Reaction - small molecule participants:
t2E-CoA [mitochondrial matrix]
H2O [mitochondrial matrix]
3HA-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-8957389
======
Reaction input - small molecules:
(R)-3-hydroxyacyl-CoA
Reaction output - small molecules:
trans-2-enoyl-CoA
water
Reactome.org link: R-HSA-8957389