Reaction: 1,25(OH)2D translocates from cytosol to nucleoplasm
- in pathway: Vitamin D (calciferol) metabolism
The biologically active form of vitamin D, 1-alpha, 25-dihydroxyvitamin D (1,25(OH)2D), can be transported to any target tissue where it enters the nucleoplasm to interact with vitamin D receptor (VDR) to exert its effects. The mechanism of translocation from cytosol to nucleoplasm is unknown (see review for general description - Christakos et al. 2016).
Reaction - small molecule participants:
1,25(OH)2D [nucleoplasm]
1,25(OH)2D [cytosol]
Reactome.org reaction link: R-HSA-8963913
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Reaction input - small molecules:
calcitriol
Reaction output - small molecules:
calcitriol
Reactome.org link: R-HSA-8963913